An anal fissure is a small tear in the thin, moist tissue mucosa that lines the anus. An anal fissure may occur when you pass hard or large stools during a bowel movement. Anal fissures typically cause pain and bleeding with bowel movements. You also may experience spasms in the ring of muscle at the end of your anus anal sphincter. Anal fissures are very common in young infants but can affect people of any age.
Morbidity associated with treatment of chronic anal fissure
Anal Fissures: A Real Pain
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Chronic anal fissure: 2% topical diltiazem hydrochloride
Introduction: Chemical sphincterotomy has proved effective in treating chronic anal fissure. Glyceryl trinitrate is the most widely used agent, and topical 0. Unfortunately, however, many patients experience troublesome headaches as a side effect of this treatment.
Nasdaq:VTUS today reported positive results from its Phase 3, randomized, double-blind, placebo-controlled clinical trial of diltiazem hydrochloride cream VEN in patients with anal fissures. Ventrus' development partner, S. Pharma, has completed most of the outputs for the statistical analysis plan of the Phase 3 trial, and Ventrus is pleased to communicate the data that they have generated.